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From: Michael Fanning on 25 Jun 2007 00:20
I was slowly falling asleep watching a program on PBS tonight about the
medical uses of various toxins found in nature when I heard mention of a
promising treatment for deadly brain tumors descibed as glioma's. I
immediately woke up and started paying attention. Apparently brain tumors
have been successfully treated with a drug derived from clorotoxin which is
a medical substance derived from scorpions living in the Arizona desert.
According to a web source I found "It targets and destroys Gleoma cells only
leaving healthy brain tissue intact." My understanding is that it is not in
use yet, but it does look like clinical trials of TM-601 the drug name for
the chemical clorotin combined with a radioactive isotope is underway.

You may have already heard of this but in case you haven't this is from the
American brain tumor association website.
Clinical Trials and Survey Announcements
This brief list represents only a few of the opportunities open to people
with a brain tumor. Visit our web site at
http://www.abta.org/findingclinicaltrials2.htm and
http://www.abta.org/internetresources4.htm to learn about other studies and
research events. If your company or institution has a trial to post in our
e-news, please e-mail us at info(a)abta.org

Chlorotoxin Study
TM-601 (also known as chlorotoxin), an experimental drug is being developed
by TransMolecular, Inc. is being studied in a phase II clinical trial whose
goal is to assess the safety and effectiveness of TM-601 when combined with
radioactive iodine (13II). TM-601 is a synthetic version of chlorotoxin, a
naturally occurring molecule derived from scorpion venom, coupled with the
radioisotope iodine 131I. This phase II study is open to people with a
high-grade glioma (glioblastoma multiforme, anaplastic astrocytoma,
anaplastic oligoastrocytoma or gliosarcoma). Participants undergo surgery to
debulk the tumor and placement of a ventricular access device used to
administer the drug directly into the tumor cavity. Surgery is followed by
either 3 or 6 weekly injections of the new drug. To learn more, visit
http://www.transmolecular.com/ or go to http://www.clinicaltrials.gov/ and
type "TM-601" into the search engine box.

God bless!







From: Michael Fanning on 25 Jun 2007 00:21
Oops, sent to this board by mistake!


"Michael Fanning" <mfanning1(a)cox.net> wrote in message
news:GoHfi.390295$ZA5.57865(a)newsfe15.phx...
>I was slowly falling asleep watching a program on PBS tonight about the
>medical uses of various toxins found in nature when I heard mention of a
>promising treatment for deadly brain tumors descibed as glioma's. I
>immediately woke up and started paying attention. Apparently brain tumors
>have been successfully treated with a drug derived from clorotoxin which is
>a medical substance derived from scorpions living in the Arizona desert.
>According to a web source I found "It targets and destroys Gleoma cells
>only leaving healthy brain tissue intact." My understanding is that it is
>not in use yet, but it does look like clinical trials of TM-601 the drug
>name for the chemical clorotin combined with a radioactive isotope is
>underway.
>
> You may have already heard of this but in case you haven't this is from
> the American brain tumor association website.
> Clinical Trials and Survey Announcements
> This brief list represents only a few of the opportunities open to people
> with a brain tumor. Visit our web site at
> http://www.abta.org/findingclinicaltrials2.htm and
> http://www.abta.org/internetresources4.htm to learn about other studies
> and research events. If your company or institution has a trial to post in
> our e-news, please e-mail us at info(a)abta.org
>
> Chlorotoxin Study
> TM-601 (also known as chlorotoxin), an experimental drug is being
> developed by TransMolecular, Inc. is being studied in a phase II clinical
> trial whose goal is to assess the safety and effectiveness of TM-601 when
> combined with radioactive iodine (13II). TM-601 is a synthetic version of
> chlorotoxin, a naturally occurring molecule derived from scorpion venom,
> coupled with the radioisotope iodine 131I. This phase II study is open to
> people with a high-grade glioma (glioblastoma multiforme, anaplastic
> astrocytoma, anaplastic oligoastrocytoma or gliosarcoma). Participants
> undergo surgery to debulk the tumor and placement of a ventricular access
> device used to administer the drug directly into the tumor cavity. Surgery
> is followed by either 3 or 6 weekly injections of the new drug. To learn
> more, visit http://www.transmolecular.com/ or go to
> http://www.clinicaltrials.gov/ and type "TM-601" into the search engine
> box.
>
> God bless!
>
>
>
>
>
>
>


From: Michael on 25 Jun 2007 00:56
Just for the record... the only reason I can think of for the US government
to have even *tried* this idea is that thy're scared to death of medical
marijuana.

http://www.nature.com/bjp/journal/v144/n8/abs/0706134a.html
Cannabidiol inhibits human glioma cell migration through a cannabinoid
receptor-independent mechanism


Michael Fanning wrote:

> Oops, sent to this board by mistake!
>
>
> "Michael Fanning" <mfanning1(a)cox.net> wrote in message
> news:GoHfi.390295$ZA5.57865(a)newsfe15.phx...
>> I was slowly falling asleep watching a program on PBS tonight about the
>> medical uses of various toxins found in nature when I heard mention of a
>> promising treatment for deadly brain tumors descibed as glioma's. I
>> immediately woke up and started paying attention. Apparently brain
>> tumors have been successfully treated with a drug derived from
>> clorotoxin which is a medical substance derived from scorpions living in
>> the Arizona desert. According to a web source I found "It targets and
>> destroys Gleoma cells only leaving healthy brain tissue intact." My
>> understanding is that it is not in use yet, but it does look like
>> clinical trials of TM-601 the drug name for the chemical clorotin
>> combined with a radioactive isotope is underway.
>>
>> You may have already heard of this but in case you haven't this is from
>> the American brain tumor association website.
>> Clinical Trials and Survey Announcements
>> This brief list represents only a few of the opportunities open to people
>> with a brain tumor. Visit our web site at
>> http://www.abta.org/findingclinicaltrials2.htm and
>> http://www.abta.org/internetresources4.htm to learn about other studies
>> and research events. If your company or institution has a trial to post
>> in our e-news, please e-mail us at info(a)abta.org
>>
>> Chlorotoxin Study
>> TM-601 (also known as chlorotoxin), an experimental drug is being
>> developed by TransMolecular, Inc. is being studied in a phase II clinical
>> trial whose goal is to assess the safety and effectiveness of TM-601 when
>> combined with radioactive iodine (13II). TM-601 is a synthetic version of
>> chlorotoxin, a naturally occurring molecule derived from scorpion venom,
>> coupled with the radioisotope iodine 131I. This phase II study is open to
>> people with a high-grade glioma (glioblastoma multiforme, anaplastic
>> astrocytoma, anaplastic oligoastrocytoma or gliosarcoma). Participants
>> undergo surgery to debulk the tumor and placement of a ventricular access
>> device used to administer the drug directly into the tumor cavity.
>> Surgery is followed by either 3 or 6 weekly injections of the new drug.
>> To learn more, visit http://www.transmolecular.com/ or go to
>> http://www.clinicaltrials.gov/ and type "TM-601" into the search engine
>> box.
>>
>> God bless!


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